Vanessa Martins Selected Research

ASTX-660

1/2021	Clinical Positioning of the IAP Antagonist Tolinapant (ASTX660) in Colorectal Cancer.
1/2018	ASTX660, a Novel Non-peptidomimetic Antagonist of cIAP1/2 and XIAP, Potently Induces TNFα-Dependent Apoptosis in Cancer Cell Lines and Inhibits Tumor Growth.

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Vanessa Martins Research Topics

Disease

13	Neoplasms (Cancer) 10/2021 - 12/2007
6	Pulmonary Fibrosis (Fibrosing Alveolitis) 09/2020 - 05/2009
6	Fibrosis (Cirrhosis) 09/2020 - 05/2009
5	Inflammation (Inflammations) 04/2021 - 05/2009
3	Melanoma (Melanoma, Malignant) 01/2018 - 04/2008
3	Prostatic Neoplasms (Prostate Cancer) 03/2010 - 11/2006
2	Sepsis (Septicemia) 01/2022 - 01/2019
2	Vascular Remodeling 04/2021 - 10/2017
2	Pneumonia (Pneumonitis) 01/2018 - 10/2017
2	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 01/2018 - 01/2018
2	Carcinoma (Carcinomatosis) 07/2010 - 04/2008
1	Septic Shock (Toxic Shock Syndrome) 01/2022
1	Colorectal Neoplasms (Colorectal Cancer) 01/2021
1	Acute Lung Injury 11/2020
1	Lung Diseases (Lung Disease) 09/2020
1	Silicosis 09/2020
1	Granuloma 09/2020
1	Autoimmune Diseases (Autoimmune Disease) 03/2020
1	Lung Injury 03/2020
1	Idiopathic Pulmonary Fibrosis 10/2018
1	Asthma (Bronchial Asthma) 01/2018
1	Airway Remodeling 01/2018
1	Malignant Pleural Effusion 12/2017
1	Adenocarcinoma 12/2017
1	Pleural Diseases 12/2017
1	Wounds and Injuries (Trauma) 10/2017
1	Pulmonary Arterial Hypertension 10/2017
1	Interstitial Lung Diseases (Interstitial Lung Disease) 01/2015
1	Pulmonary Emphysema 12/2012
1	Emphysema 12/2012

Drug/Important Bio-Agent (IBA)

7	Bleomycin (Blenoxane)FDA LinkGeneric 09/2020 - 05/2009
6	CollagenIBA 04/2021 - 01/2015
6	Proteins (Proteins, Gene)FDA Link 01/2021 - 01/2008
3	Phosphotransferases (Kinase)IBA 01/2021 - 07/2012
3	Abiraterone AcetateIBA 03/2010 - 11/2006
2	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 01/2022 - 11/2020
2	ASTX029IBA 10/2021 - 01/2021
2	Collagen Type V (Type V Collagen)IBA 04/2021 - 10/2018
2	ASTX-660IBA 01/2021 - 01/2018
2	InterleukinsIBA 03/2020 - 01/2018
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 12/2017 - 10/2017
2	DNA (Deoxyribonucleic Acid)IBA 05/2012 - 12/2007
2	Steroid 17-alpha-Hydroxylase (17 alpha Hydroxylase)IBA 03/2010 - 10/2008
2	5- (2,4- dihydroxy- 5- isopropylphenyl)- 4- (4- morpholin- 4- ylmethylphenyl)isoxazole- 3- carboxylic acid ethylamideIBA 04/2008 - 01/2008
1	olaparibIBA 01/2022
1	Ribosomal Protein S6 Kinases (S6 Kinase)IBA 10/2021
1	Histone Deacetylases (Histone Deacetylase)IBA 01/2021
1	3- (2- (2- tert- butylphenylaminooxalyl)aminopropionylamino)- 4- oxo- 5- (2,3,5,6- tetrafluorophenoxy)pentanoic acidIBA 01/2021
1	Caspase 10IBA 01/2021
1	Caspase 8 (Caspase-8)IBA 01/2021
1	Mitogen-Activated Protein KinasesIBA 01/2021
1	CaspasesIBA 01/2021
1	Fluorouracil (Carac)FDA LinkGeneric 01/2021
1	EnzymesIBA 11/2020
1	PPAR gammaIBA 09/2020
1	Silicon Dioxide (Silica)FDA LinkGeneric 09/2020
1	Interleukin-17 (Interleukin 17)IBA 03/2020
1	Conditioned Culture MediaIBA 03/2020
1	CytokinesIBA 03/2020
1	Glutamine (L-Glutamine)FDA Link 01/2019
1	alanylglutamineIBA 01/2019
1	Corn Oil (Oil, Corn)IBA 10/2018
1	Butylated Hydroxytoluene (BHT)IBA 10/2018
1	AmphiregulinIBA 01/2018
1	Biological ProductsIBA 01/2018
1	Eicosapentaenoic AcidIBA 01/2018
1	Dinoprostone (PGE2)FDA Link 01/2018
1	Cell Adhesion MoleculesIBA 01/2018
1	Matrix Metalloproteinases (MMPs)IBA 01/2018
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2018
1	MAP Kinase Kinase Kinases (MAP Kinase Kinase Kinase)IBA 01/2018
1	Metalloproteases (Metalloproteinases)IBA 01/2018
1	Syndecan-1 (Syndecan 1)IBA 01/2018
1	PeptidomimeticsIBA 01/2018
1	DecorinIBA 01/2018
1	MonocrotalineIBA 10/2017
1	Platelet-Derived Growth FactorIBA 10/2017
1	Inhibitor of Apoptosis ProteinsIBA 08/2015
1	tyrosine receptor (receptor, tyrosine)IBA 07/2015
1	Collagen Type I (Type I Collagen)IBA 01/2015
1	Messenger RNA (mRNA)IBA 01/2015
1	Hydroxyproline (4 Hydroxyproline)IBA 01/2015
1	Telomerase (Telomerase Reverse Transcriptase)IBA 01/2015
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 12/2012
1	Superoxide DismutaseIBA 12/2012
1	NitritesIBA 12/2012
1	Pancreatic Elastase (Elastase)IBA 12/2012
1	Malondialdehyde (Propanedial)IBA 12/2012
1	rho-Associated KinasesIBA 07/2012
1	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 07/2012
1	70-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)IBA 07/2012
1	AT13148IBA 07/2012

Therapy/Procedure

6	Therapeutics 01/2018 - 10/2008
2	Castration 03/2010 - 10/2008
1	Investigational Therapies (Experimental Therapy) 01/2022
1	Adjuvant Chemotherapy 01/2021
1	Aftercare (After-Treatment) 03/2020
1	Punctures 01/2019
1	Ligation 01/2019
1	Artificial Respiration (Mechanical Ventilation) 01/2018